Name | Chloroacetic acid |
Synonyms | chloroacetate Chloroacetic acid acidechloroacetique Monochloroacetic acid Acidomonocloroacetico acidemonochloracetique Mono Chloro Acetic Acid alpha-Chloroacetic acid Chloroacetic acid, mono- acidechloroacetique(french) acidemonochloracetique(solide) acidemonochloracetique(french) acidemonochloracetique(solutions) |
CAS | 79-11-8 |
EINECS | 201-178-4 |
InChI | InChI=1/C2H3ClO2/c3-1-2(4)5/h1H2,(H,4,5)/p-1 |
Molecular Formula | C2H3ClO2 |
Molar Mass | 94.5 |
Density | 1.58 |
Melting Point | 60-63 °C (lit.) |
Boling Point | 189 °C (lit.) |
Flash Point | 126°C |
Water Solubility | SOLUBLE |
Solubility | Soluble in methanol, acetone, diethyl ether, benzene, chloroform and ethanol. |
Vapor Presure | 0.75 mm Hg ( 20 °C) |
Vapor Density | 3.26 (vs air) |
Appearance | Liquid |
Color | White |
Odor | Penetrating, burning odor |
Merck | 14,2112 |
BRN | 605438 |
pKa | 2.85(at 25℃) |
Storage Condition | Store below +30°C. |
Stability | Stable. Deliquescent. Incompatible with strong bases, alkalies, most common metals, strong oxidizing agents. |
Sensitive | Hygroscopic |
Explosive Limit | 8% |
Refractive Index | 1.4330 |
Physical and Chemical Properties | Colorless or light yellow crystals, irritating odor, easy deliquescence. There is a strong corrosive. melting point 63 ℃(α-type) boiling point 187.85 ℃ freezing point relative density 1.4040 refractive index 1.4330 flash point solubility: soluble in water and ethanol, most organic solvents such as ether. |
Use | Dye Industry for the production of indigo dyes; Pharmaceutical industry for the synthesis of caffeine, barbiturate, epinephrine; Pesticide industry for the manufacture of dimethoate, herbicides |
Risk Codes | R25 - Toxic if swallowed R34 - Causes burns R50 - Very Toxic to aquatic organisms R40 - Limited evidence of a carcinogenic effect R36/37/38 - Irritating to eyes, respiratory system and skin. R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R38 - Irritating to the skin |
Safety Description | S23 - Do not breathe vapour. S37 - Wear suitable gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. S63 - S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
UN IDs | UN 1751 6.1/PG 2 |
WGK Germany | 2 |
RTECS | AF8575000 |
FLUKA BRAND F CODES | 3 |
TSCA | Yes |
HS Code | 29154000 |
Hazard Class | 6.1 |
Packing Group | II |
colorless or light yellow crystals, irritating odor, easy deliquescence. Strong corrosive, can corrode the skin, damage all non-precious metals, rubber and wood. Soluble in water and ethanol, ether and other most organic solvents. There are four types of crystals.
This product is an organic chemical raw materials, mainly used as pesticides, pharmaceuticals and dyes intermediates. Pesticide industry for the production of dimethoate, herbicide 2,4-D and butyl ester, 2,4 ,5-T, thiocyanacetic acid and a naphthalene acetic acid; Pharmaceutical industry for the synthesis of caffeine, barbiturate, epinephrine, vitamin B. And glycine; Used in the dye industry for the production of indigo dyes. Chloroacetic acid can also be used in the production of carboxymethyl cellulose (CMC) and non-ferrous metal flotation agent 2-200#, can also be used as a chromatographic analysis reagent.
category
High toxicity grade
Acute oral toxicity-rat LD50: 580 mg/kg; Subcutaneous-mouse LD50: 250 mg/kg
Explosive hazard characteristics and explosive properties of air mixture
Flammable hazard characteristics: when exposed to heat, open flame combustion; Toxic phosgene generated by thermal decomposition; Corrosive
Storage and Transportation characteristics the warehouse is ventilated and dried at low temperature; It is stored separately from oxidants and alkalis.
Fire extinguishing agent foam, water mist, carbon dioxide
Occupational Standards TLV-TWA 0.5 mg/m; PEL 1 mg/m
China's production by acetic acid chlorination method: the quantitative glacial acetic acid is added to the reaction pot, with 3.5% sulfur powder by weight of glacial acetic acid as the catalyst, preheating to more than 90 ℃, and the appropriate amount of chlorine gas is introduced, two reaction pots were connected to each other with chlorine. The main pot was controlled at 98±2 ℃, and the auxiliary pot was controlled at 85-90 ℃, when the relative density of the materials in the reaction pan is 1.350(80 ° C.), the end point of the reaction is reached. The reactant is pumped to the acid tank, cooled and crystallized, and the liquid phase is a small amount of acetic acid, dichloroacetic acid, sulfur chloride and a small amount of chloroacetic acid. The crystal is separated and the mother liquor is pumped down to 38 ℃. About 150 of mother liquor is produced per ton of product and can be further chlorinated to dichloroacetic acid, methyl dichloroacetate and chloroform. Trichloroethylene water method at the same time the addition of water and hydrolysis: the reaction temperature of 160-180 deg C, the reaction concentration of sulfuric acid should be maintained at 93%, control the ratio of trichloroethylene and water. The consumption of sulfuric acid is not more than 30%, and 2.57t hydrochloric acid is produced as by-product. Industrial chloroacetic acid is colorless or slightly yellowish crystals. Raw material consumption quota: glacial acetic acid (98%)730kg/t, chlorine 860kg/t, sulfur 26kg/t.
pH range of acid-base indicator discoloration | < 1 at 800g/l at 20°C |
Solvent | Sterile water in sealed ampoule |
Concentration | 1 mCi/ml |
Specific Activity | 5-10 Ci/mmol |
LogP | 0.49 at 20℃ |
NIST chemical information | information provided by: webbook.nist.gov (external link) |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Use | the dye industry is used for the production of indigo dyes, and the pharmaceutical industry is used for the synthesis of caffeine, barbiturate, epinephrine, etc, pesticide industry for the manufacture of dimethoate, herbicides, etc. chloroacetic acid is an organic chemical raw materials, widely used in the production of pesticides, can be used for the synthesis of organophosphorus insecticides dimethoate, omethoate intermediate methyl chloroacetate, the intermediate of quetiapine, 2-hydroxyquinoline, herbicide 2,4-drop, 2,4-drop butyl ester, 2 methyl 4 chloride, glyphosate, imazol-Furon and plant growth regulator naphthylacetic acid, etc. Also used in dyes, pharmaceuticals, resins and other organic synthesis. used in a wide range of organic synthesis materials. Dye Industry for the production of indigo, naphthalene amino acetic acid dyes; In the pharmaceutical industry for the synthesis of caffeine, barbiturate, epinephrine, vitamin B6, amino acetic acid, malonate and other drugs and intermediates; in the pesticide industry for the production of herbicides 2,4-D, butyl ester, 2,4,5-T, thiocyanacetic acid, α-naphthylacetic acid, glyphosate, alachlor, acetochlor, butachlor and insecticide dimethoate more than 20 kinds of pesticides; in the synthetic fiber industry for the production of carboxymethyl cellulose (CMC) and non-ferrous metal flotation agent Z-200#, can also be used as a color layer analysis reagent, can also be used for food additives, detergents, cold Red fine and other products. See the chloroacetic acid series products in the attached table of this article for details. as an excellent flame retardant for polyamide, PVC can replace part of antimony trioxide in flame retardant and smoke suppression, and has good lubricity |
production method | There are three main methods for the industrial production of chloroacetic acid. (1) the acetic acid chlorination method is obtained by directly chlorination of acetic acid with chlorine gas in the presence of a catalyst such as iodine, phosphorus, sulfur or a halide of phosphorus and sulfur. In addition to the formation of chloroacetic acid, there are deep chlorination by-products such as dichloroacetic acid, trichloroacetic acid. The process is simple and the yield of chloroacetic acid can reach 92%. (2) trichloroethylene hydration method is based on 93% sulfuric acid as catalyst, reaction temperature is about 160-180 deg C. Chloroacetic acid with high purity can be obtained by this method, and the yield can reach 90%, but more hydrochloric acid is by-product. (3) the chloroethanol oxidation method is oxidation with 60% nitric acid at 60 ° C., and the yield of chloroacetic acid is more than 90%. In North America to acetic acid chloride method, Western Europe to trichloroethylene water law. China's production by acetic acid chlorination method: the quantitative glacial acetic acid is added to the reaction pot, with 3.5% sulfur powder by weight of glacial acetic acid as catalyst, preheating to more than 90 degrees Celsius, and the appropriate amount of chlorine gas is introduced, two reaction pots were connected to each other with chlorine. The main pot was controlled at 98±2 ℃, and the auxiliary pot was controlled at 85-90 ℃, the relative density of the materials in the reaction pan is 1.350(80 C). When, that is, the reaction reaches the end point. The reactant is pumped to the acid tank, cooled and crystallized, and the liquid phase is a small amount of acetic acid, dichloroacetic acid, sulfur chloride and a small amount of chloroacetic acid. The crystal is separated and the mother liquor is pumped down to 38 ℃. About 150 of mother liquor is produced per ton of product and can be further chlorinated to dichloroacetic acid, methyl dichloroacetate and chloroform. Trichloroethylene water method at the same time the addition of water and hydrolysis: the reaction temperature of 160-180 deg C, the reaction concentration of sulfuric acid should be maintained at 93%, control the ratio of trichloroethylene and water. The consumption of sulfuric acid is not more than 30%, and 2.57t hydrochloric acid is produced as by-product. Industrial chloroacetic acid is colorless or slightly yellowish crystals. Raw material consumption quota: glacial acetic acid (98%)730kg/t, chlorine 860kg/t, sulfur 26kg/t. There are many synthetic methods of chloroacetic acid, such as acetic acid chlorination, acetic anhydride catalyzed chlorination, trichloroethylene hydrolysis, glycolic acid chlorination, tetrachloroethane hydrolysis, etc, the advantage of this method is that no sulfuric acid is used, and the raw material price is cheap, CH3COOH + Cl2 → ClCH2COOH + HCl quantitative glacial acetic acid is added to the reaction pot, 3.5% sulfur powder of glacial acetic acid mass is used as catalyst, after preheating to more than 90 ℃, the appropriate amount of chlorine gas is introduced, and the two reaction pots are connected with each other. The control temperature of the main pot is (98±2)℃, and the auxiliary pot is 85~90 ℃, the chlorine gas flow rate was about 70kg/h. The relative density of the materials in the reaction pan is 1.350(80 C). The end point of the reaction is reached. The reactants were pumped to the acid tank, cooled to crystallize, the crystals were separated, and the mother liquor was drained below 38 °c to obtain the finished chloroacetic acid. In addition, some experiments show that, in addition to sulfur powder, acetic anhydride can also play a good catalytic effect on the above chlorination reaction under the same conditions, and the effect is better than that of sulfur powder. Also trichloroethylene water legal. Trichloroethylene reacts with concentrated sulfuric acid, the reaction temperature is 160~180 ℃, the sulfuric acid content is maintained at 93%, the ratio of trichloroethylene to water is controlled, and the reaction process is added and hydrolyzed with sulfuric acid to obtain monochloroacetic acid. |
category | corrosive article |
toxicity grade | high toxicity |
Acute toxicity | oral-rat LD50: 580 mg/kg; Subcutaneous-mouse LD50: 250 mg/kg |
explosive hazard characteristics | explosive when mixed with air |
flammability hazard characteristics | when heated, open flame combustion; Thermal decomposition to produce toxic phosgene; corrosive |
storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from oxidants and alkalis. |
fire extinguishing agent | foam, water mist, carbon dioxide |
Occupational Standard | TLV-TWA 0.5 mg/m3; Tel 1 mg/m3 |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |